Stability of Reconstituted IV Injections
#MarchProject2025#Preview Introduction Unlike outpatient pharmacies, inpatient pharmacies also handle injectable medications. Ampoules are typically single-use containers; once opened, they cannot be resealed, and any remaining medication must be discarded. In contrast, reconstituted powdered drugs can sometimes be stored for a limited time, depending on their chemical and physical stability, which varies between brands. To reduce costs, a reconstituted vial is ideally used for multiple doses. For example, a 1 g vial could provide three 300 mg doses. The stability data for some common reconstituted IV preparations are shown below. For simplicity, this discussion excludes ampoule injections and the stability of reconstituted injections after dilution in various diluents (e.g., normal saline or 5% dextrose). Summary