Stability of Reconstituted IV Injections

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Introduction

Unlike outpatient pharmacies, inpatient pharmacies also handle injectable medications.

• Ampoules are typically single-use containers; once opened, they cannot be resealed, and any remaining medication must be discarded.
• In contrast, reconstituted powdered drugs can sometimes be stored for a limited time, depending on their chemical and physical stability, which varies between brands.
• To reduce costs, a reconstituted vial is ideally used for multiple doses. For example, a 1 g vial could provide three 300 mg doses.

The stability data for some common reconstituted IV preparations are shown below.

• For simplicity, this discussion excludes ampoule injections and the stability of reconstituted injections after dilution in various diluents (e.g., normal saline or 5% dextrose).

Summary