Laboratory Data
Introduction
- Differentiate among possible diagnoses
- Confirm a diagnosis
- Assess current status
- Evaluate the response to therapy
when history and physical exam alone are insufficient
Related tests may be grouped together into a set called a profile or a panel, although small differences may exist between institutions panels.
Reference Range
The reference range is a statistically derived numeric range obtained by testing a sample of individuals assumed to be healthy. It is usually established as the mean ± 2 standard deviations.
- Reference ranges can vary between laboratories and facilities due to differences in analytic techniques, reagents and equipment.
- Reference ranges may also differ among populations and may change as new data are published.
The 'normal range' should be used with caution as it takes little account of an individual's age, sex, weight, height, muscle mass or disease state, many of which variables can influence test results.
NOTE: Abnormal values are not always clinically significant, and in some diseases or conditions, values within the reference range can be considered abnormal.
Interpretation Key Points
Laboratory results must be interpreted in context of the patient (i.e. clinical condition) and the limitations of the laboratory test.
- The presence or absence of signs and symptoms associated with the medical problem outweighs an isolated laboratory report.
Baseline results, rate of change and patterns should be considered when interpreting laboratory results.
- A disturbance of one parameter often cannot be considered in isolation without looking at the pattern of other tests within the group.
- For instance, the severity of infection is often reflected by parameters such as body temperature, white cell count, C-reactive protein and procalcitonin (indicative of bacterial infection).
- Conversely, renal function can be assessed through key parameters including creatinine clearance, albuminuria, urea and urine output.
- A series of values rather than a simple test value may be required in order to ensure clinical relevance and to eliminate erroneous values caused.
If laboratory error is suspected, the test should be repeated.
- Laboratory error is an uncommon occurrence; however, it can happen.
- Potential causes of laboratory error include technical error, improper calculation, inadequate specimen, incorrect sampling timing, improper sample preservation, food substances affecting specimen, or medication interference with lab tests.
NOTE: May refer Critical Care Pharmacy Handbook for management of abnormalities in plasma sodium, potassium, calcium, magnesium and phosphate.
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