Dilution Protocol

Introduction

Medication administration errors can have a number of negative consequences, including

  • Increased costs
  • Prolonged hospital stays
  • Psychological distress
  • Loss of public confidence in healthcare
  • Patient morbidity or mortality

To help prevent medication administration errors, it is important to have clear and accurate guidelines for the dilution and administration of injectable drugs.



Malaysia

Published in 2011, the Dilution Guide for High Alert Medications serves as a general resource for the approppriate use of HAMs.

Dilution Guide for High Alert Medications

While informative, the JKN Selangor Dilution Protocol 2017 only covers a select number of drugs.

JKN Selangor Dilution Protocol

The Dilution Guideline for Injectable Drugs, 2020 is a general reference for healthcare professionals on how to prepare dilutions of certain injectable drugs before administering them to patients.

  • The guideline currently only covers Part 1, which focuses on antimicrobials.

Dilution Guideline for Injectable Drugs

In 2022, Antidote Quick Guide (Adult Dose) is prepared to facilitate the healthcare professional to react fast to poisoning and overdose injuries.

Antidote Quick Guide

This is followed by the publication of the Dilution Guide for Fluid-restricted Critically Ill Adults in 2024.

Dilution Guide for Fluid-restricted Critically Ill Adults

However, as new drugs are approved and existing drugs are modified, a more dynamic and accessible website or mobile application would be a better format for this guideline.

  • This format would allow all drugs to be searchable in one database, with continuous updates made as new information becomes available.



Established Injectable Drug Reference

Some of the most popular injectable drug references include

NOTE: Lexicomp and Micromedex both use Trissel's Clinical Pharmaceutics Content for their IV compatibility databases, so there is no significant difference in the information they offer. Hence, if you are looking for additional information on IV compatibility and stability data, you may want to consult other references, such as King Guide or ASHP Injectable Drug Information.



External Links

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