Renal Drug Dosing References

Introduction

Individualization of a drug dosage regimen for a patient with impaired kidney function is based on

• the pharmacodynamic/pharmacokinetic characteristics of the drug,
• the patient's degree of residual renal function, and
• the patient's overall clinical condition.

Common methods of dose adjustment are to

• Reduce the dose while maintaining the common dosing interval
• Maintain the dose while extending the dosing interval, or
• Both

However, the drug dosing guidelines for CKD patients in many drug information sources are highly variable.

Standard References

On top of product leaflet, most pharmacists might also consider to check up these standard references when come to renal dosage adjustment in CKD patients.

• AHFS Drug Information
• Australian Medicines Handbook
• British National Formulary
• Micromedex
• Lexicomp
• Medscape

Aronoff's Drug Prescribing in Renal Failure, 2007

Drug Prescribing in Renal Failure focuses on drug dosing in patients with impaired kidney function. The information takes the form of a "Recommendation Level" and is added to the columns "Adjustment for Renal Failure" and "Supplement for Dialysis" as follows.

• A - Recommendations derived from human trials larger than a case study
• B - Recommendations derived from human case study
• C - Recommendations derived from in vitro data
• D - Recommendations derived from the authors' educated assessment based on the pharmacokinetics and pharmacodynamics of the drug

However, this book is last updated in 2007 and hence, newer evidence and drugs may not be included.

Demystifying Drug Dosing in Renal Dysfunction, 2019

Demystifying Drug Dosing in Renal Dysfunction serves as a quick reference for commonly used medication dosing given varying degrees of renal dysfunction and/or use of renal replacement modalities.

• Data are presented to allow the practitioner to understand the nuances considered when developing the dosing recommendations.

The Renal Drug Handbook, 2019

The Renal Drug Handbook is an invaluable guide in which the information has been compiled from a wide range of sources and from the clinical experience of the UK Renal Pharmacy Group. It provides detailed drug information (over 900 drug monographs) to assist healthcare professionals to safely dose medications in patients with kidney disease.

Renal Pharmacotherapy, 2021

Renal Pharmacotherapy is a comprehensive listing of dosage recommendations of systemic medications for adult patients with compromised renal function. This document was originally designed for use by those who are competent healthcare professionals employed by or directly connected and having privileges with the University of Colorado Hospital who rely on their clinical judgement and discretion.